Doctors still do not understand how Retin-A reduce melasma. Probably the best explanation goes like this. Retin-A is used for skin exfoliation to encourage new cells to be generated. This process removes dead skin cells which build up on the surface of the skin and hold excess melanin within them.
According to Skin Care Center, it may take up to 24 weeks to see improvements. Most often, Retin-A is used together with other tyrosinase inhibitors such as azelaic acid or hydroquinone for better results.
